Description

Columbamine CAS NO 3621-36-1 is a naturally occurring isoquinoline alkaloid, a key intermediate and reference standard in pharmaceutical and phytochemical research. Its significance lies in its role as a precursor in the biosynthesis of other bioactive alkaloids and its own potential pharmacological properties. This compound is essential for research and development laboratories in the pharmaceutical, nutraceutical, and botanical extract industries, particularly those focused on natural product chemistry and drug discovery.

Application

• Pharmaceutical Reference Standard: Used for the identification, purity testing, and quantification of columbamine in raw materials and finished products via analytical methods like HPLC and LC-MS.
• Biochemical Research: Serves as a crucial intermediate and tool compound for studying the biosynthesis pathways of protoberberine and related isoquinoline alkaloids in plants.
• Natural Product Isolation & Analysis: Employed as a marker compound for the quality control and standardization of botanical extracts, particularly from plants in the families Berberidaceae and Menispermaceae.
• Pharmacological Studies: Investigated for its potential biological activities, which may include anti-inflammatory, antimicrobial, or metabolic effects, supporting early-stage drug discovery.
• Chemical Synthesis: Acts as a valuable chiral building block or precursor for the semi-synthesis of more complex alkaloids and novel chemical entities.

Basic Information

Product Name	Columbamine
CAS No.	3621-36-1
Molecular Formula	C₂₀H₂₀NO₄⁺
Molecular Weight	338.38 g/mol
Synonyms	Columbamine; 8,13-Dioxo-5,6,13,13a-tetrahydro-9,10-dimethoxy-6-methylberbin-7-ium; 2,3,9,10-Tetramethoxyprotoberberin-7-ium; (S)-Columbamine; Isoquinolinium, 5,6-dihydro-2,3,9,10-tetramethoxy-7H-dibenzo[a,g]quinolizin-7-ylidene-; Columbamine cation
EINECS	Contact for details

Quality Control

Our Columbamine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR) and purity determination by HPLC, to ensure it meets high-purity research-grade standards. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.