Description

(1S,14R)-1,2-Dihydro-12,14α-Dihydroxysenecionan-11,16-Dione is a high-purity pyrrolizidine alkaloid derivative of significant interest in advanced research and development. This compound serves as a critical reference standard and a sophisticated synthetic intermediate for exploring novel bioactive molecules. It is primarily sought after by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on natural product chemistry and medicinal chemistry programs.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of pyrrolizidine alkaloids in drug discovery and quality control processes.
• Medicinal Chemistry Research: Acts as a key intermediate or precursor in the synthesis of novel compounds for biological activity screening.
• Natural Product Isolation & Study: Serves as a benchmark compound in the isolation, identification, and metabolic study of senecionine-related alkaloids from plant sources.
• Biochemical Research: Utilized in studies investigating the mechanism of action, toxicity, and metabolic pathways of hepatotoxic pyrrolizidine alkaloids.
• Analytical Method Development: Employed as a calibrant in developing and validating advanced analytical methods such as HPLC-MS and GC-MS for alkaloid detection.

Basic Information

Product Name	(1S,14R)-1,2-Dihydro-12,14α-Dihydroxysenecionan-11,16-Dione
CAS No.	3573-82-8
Molecular Formula	C18H25NO5
Molecular Weight	335.40 g/mol
Synonyms	12,14α-Dihydroxysenecionan-11,16-dione; 1,2-Dihydro-12,14α-dihydroxysenecionan-11,16-dione; Senecionine derivative; (1S,14R)-12,14α-Dihydroxysenecionan-11,16-dione; Pyrrolizidine alkaloid intermediate; PA reference standard
EINECS	Contact for details

Quality Control

Our (1S,14R)-1,2-Dihydro-12,14α-Dihydroxysenecionan-11,16-Dione is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic and spectroscopic methods. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.