Description

Eicosatrienoic Acid, 8,11,14-, [1-14C] is a carbon-14 radiolabeled analog of the polyunsaturated fatty acid, dibomo-γ-linolenic acid (DGLA). This labeled compound is essential for metabolic pathway tracing, pharmacokinetic studies, and lipid metabolism research, providing critical insights into the biosynthesis of eicosanoids. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors for precise analytical applications.

Application

• Biochemical Research & Metabolic Tracer Studies: Used as a radiolabeled tracer to investigate the metabolism, distribution, and biochemical fate of dibomo-γ-linolenic acid and its derivatives.
• Pharmaceutical Development: Employed in drug discovery and development for studying the pharmacokinetics and pharmacodynamics of lipid-based therapeutics and anti-inflammatory agents.
• Lipidomics & Analytical Chemistry: Serves as an internal standard or reference material in mass spectrometry and HPLC for the accurate quantification of fatty acids and eicosanoids in complex biological matrices.
• Enzyme Activity Assays: Used in in vitro assays to study the activity of enzymes like δ5-desaturase and cyclooxygenase in the arachidonic acid cascade.
• Nutritional Science: Applied in research on essential fatty acid metabolism, dietary impacts, and the role of DGLA in human health and disease.
• Chemical Synthesis Intermediate: Acts as a labeled building block for the synthesis of more complex, isotopically labeled bioactive molecules and prostaglandins.

Basic Information

Product Name	Eicosatrienoic Acid, 8,11,14-, [1-14C]
CAS No.	3435-80-1
Molecular Formula	C20H34O2 (with 14C at position 1)
Molecular Weight	~306.5 g/mol (unlabeled)
Synonyms	8,11,14-Eicosatrienoic acid, [1-14C]; (8Z,11Z,14Z)-Icosatrienoic acid-1-14C; DGLA-1-14C; Dihomo-γ-linolenic acid-1-14C; 20:3, n-6 (8,11,14)-1-14C; all-cis-8,11,14-Eicosatrienoic acid-1-14C; 8Z,11Z,14Z-Eicosatrienoic acid-1-14C; Radiolabeled DGLA
EINECS	222-332-1 (for unlabeled compound)

Quality Control

Every batch of Eicosatrienoic Acid, 8,11,14-, [1-14C] is manufactured and analyzed under strict quality protocols to ensure high chemical and radiochemical purity, identity, and stability. Our quality system ensures traceability and compliance with relevant guidelines for radioactive materials. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity (typically >97% by radio-HPLC), chemical purity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and radiolytic decomposition. For long-term storage, solutions are recommended to be kept in amber vials at the specified temperature. Users must adhere to all local and international regulations for the safe handling and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution (in specified solvent)
Identification (IR / NMR)	Conforms to structure
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Concentration	0.1 mCi/mL in ethanol (or as specified)
Solvent	Ethanol, Toluene, or other specified solvent
Radioisotope	Carbon-14 (14C)
Position of Label	Carbon-1 (Carboxyl carbon)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.