Description

Z-Leu-Osu CAS NO 3397-35-1 is a high-purity, protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over the coupling of leucine residues, ensuring high yields and minimal racemization. It is a critical reagent for pharmaceutical R&D, particularly in the development of therapeutic peptides and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A crucial reagent for the efficient and selective incorporation of leucine into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical peptide bond formation strategies for research-scale and industrial production.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex peptide-based drugs and APIs.
• Bioconjugation: Facilitates the site-specific labeling or modification of proteins and other biomolecules.
• Proteomics Research: Employed in the chemical synthesis of peptide standards, probes, and substrates for enzymatic studies.
• Combinatorial Chemistry: Used in libraries for drug discovery to explore structure-activity relationships.

Basic Information

Product Name	Z-Leu-Osu
CAS No.	3397-35-1
Molecular Formula	C15H18N2O6
Molecular Weight	322.32 g/mol
Synonyms	N-Carbobenzoxy-L-leucine N-hydroxysuccinimide ester; Z-L-Leucine N-succinimidyl ester; Cbz-L-Leucine N-succinimidyl ester; Nα-Benzyloxycarbonyl-L-leucine N-hydroxysuccinimide ester; Nα-Cbz-L-leucine N-hydroxysuccinimide ester; Z-Leu-OSu; NSC 334905; Benzyl N-[(2S)-4-methyl-1-oxo-1-[(2,5-dioxopyrrolidin-1-yl)oxy]pentan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Leu-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, to meet the stringent requirements of pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: -15.0° to -18.0° (c=1 in DMF)
Melting Point	108°C - 112°C
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.