Description

(3B,5B,7A,12A)-3,7,12-Trihydroxy-Cholan-24-Oic Acid CAS NO 3338-16-7 is a high-purity bile acid derivative, a key intermediate in the synthesis of pharmaceutical compounds. Its defined stereochemistry and hydroxyl group pattern make it a critical building block for producing therapeutic agents targeting liver and metabolic functions. This compound is essential for research and manufacturing in the pharmaceutical and biotechnology sectors, where precise molecular structure is paramount for efficacy and regulatory approval.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of ursodeoxycholic acid (UDCA) and other therapeutic bile acids.
• Biochemical Research: Used as a standard or reagent in studies of bile acid metabolism, hepatobiliary function, and cholesterol homeostasis.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a starting material or advanced intermediate in the production of APIs for liver disease and cholesterol-lowering medications.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical products.
• Metabolic Pathway Studies: Utilized in in-vitro and in-vivo research to investigate the role of bile acids in digestion and metabolic disorders.

Basic Information

Product Name	(3B,5B,7A,12A)-3,7,12-Trihydroxy-Cholan-24-Oic Acid
CAS No.	3338-16-7
Molecular Formula	C24H40O5
Molecular Weight	408.57 g/mol
Synonyms	Cholic Acid; 3α,7α,12α-Trihydroxy-5β-cholan-24-oic Acid; 5β-Cholan-24-oic Acid-3α,7α,12α-triol; 3,7,12-Trihydroxycholanic Acid; Cholalic Acid; Colalin; Gallogen; Phocol; 1,3,7-Trihydroxycholan-24-oic Acid
EINECS	222-055-0

Quality Control

Our (3B,5B,7A,12A)-3,7,12-Trihydroxy-Cholan-24-Oic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and melting point, and specific tests for residual solvents and related substances. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Melting Point	198°C - 202°C
Assay (HPLC)	≥ 98.0%
Specific Rotation	+36° to +38° (c=1, in Ethanol)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.