Description

Difenidol Hydrochloride CAS NO 3254-89-5 is a pharmaceutical-grade active pharmaceutical ingredient (API) primarily used as an antiemetic and antivertigo agent. It is a critical component in the formulation of medications designed to treat and prevent nausea, vomiting, and dizziness associated with conditions like motion sickness and Meniere's disease. This compound is essential for pharmaceutical manufacturers and research institutions developing therapeutic solutions for vestibular and gastrointestinal disorders. We supply high-purity Difenidol Hydrochloride to meet the stringent requirements of global pharmaceutical production and advanced clinical research.

Application

• Pharmaceutical API: Primary active ingredient in prescription antiemetic and antivertigo medications.
• Motion Sickness Treatments: Formulation of tablets, capsules, or injectables for the prevention and treatment of nausea and vomiting due to motion.
• Meniere's Disease Management: Used in therapeutic regimens to alleviate vertigo and associated symptoms.
• Post-Operative Care: Prevention of nausea and vomiting following surgical procedures.
• Vestibular Disorder Research: Key reference standard and biochemical tool in neurological and pharmacological research.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic pharmaceutical products.

Basic Information

Product Name	Difenidol Hydrochloride
CAS No.	3254-89-5
Molecular Formula	C21H27NO • HCl
Molecular Weight	345.91 g/mol
Synonyms	1,1-Diphenyl-4-piperidino-1-butanol Hydrochloride; Diphenidol Hydrochloride; Difenidol HCl; Vontrol; Cephadol; SK&F 478
EINECS	221-857-6

Quality Control

Our Difenidol Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmacopeial standards suitable for pharmaceutical use. We provide Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, with traceability for full quality assurance. Our commitment to cGMP compliance and regulatory documentation supports seamless integration into your global supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.