Description

Estradiol 17-Sulfate is a sulfated metabolite of the primary female sex hormone, estradiol. This water-soluble conjugate is a critical reference standard and intermediate in pharmaceutical research and development, particularly for studying estrogen metabolism and hormone replacement therapies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors requiring high-purity biochemicals for analytical and synthetic applications.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quality control and method validation in drug development and bioanalytical studies.
• Biochemical Research: Critical reagent for investigating estrogen sulfation pathways, enzyme kinetics (sulfotransferases), and hormone metabolism in vitro and in vivo.
• Diagnostic Kit Development: Used in the calibration and development of immunoassays and LC-MS/MS kits for the precise quantification of estrogen metabolites in clinical samples.
• Metabolite Synthesis: Serves as a key intermediate or precursor in the organic synthesis of other estrogen derivatives and labeled compounds for tracer studies.
• Academic & Institutional Research: Supports fundamental endocrinology and toxicology research in universities and government laboratories.

Basic Information

Product Name	Estradiol 17-Sulfate
CAS No.	3233-69-0
Molecular Formula	C18H22O5S
Molecular Weight	350.43 g/mol
Synonyms	Estradiol 17-Sulfate; Estradiol 17β-Sulfate; 17β-Estradiol 17-Sulfate; Estr-1,3,5(10)-triene-3,17β-diol 17-Sulfate; 3,17β-Dihydroxy-1,3,5(10)-estratriene 17-Sulfate; Estradiol 17-(Hydrogen Sulfate); NSC 121773; 17β-Estradiol 17-(Sulfuric Acid Ester)
EINECS	221-775-1

Quality Control

Our Estradiol 17-Sulfate is manufactured and tested under a strict quality management system. Each batch is analyzed to ensure high chemical purity and identity, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and identification results is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.