Description

Epi-Doxycycline CAS NO 3219-99-6 is a tetracycline derivative and an epimer of the broad-spectrum antibiotic doxycycline. This compound is of significant interest in pharmaceutical research and development, particularly for its role as a key intermediate or reference standard in the synthesis and analytical profiling of tetracycline-class antibiotics. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of novel antibacterial agents, quality control processes, and metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthetic pathways for novel tetracycline antibiotics and their analogs.
• Analytical Reference Standard: Used in High-Performance Liquid Chromatography (HPLC), mass spectrometry, and other analytical methods for the identification, assay, and impurity profiling of doxycycline and related compounds.
• Biochemical Research: Employed in microbiological and pharmacological studies to investigate the structure-activity relationships (SAR) and resistance mechanisms of tetracycline antibiotics.
• Quality Control & Regulatory Compliance: Essential for pharmaceutical quality assurance laboratories to validate methods and ensure batch-to-batch consistency in antibiotic production, supporting compliance with FDA, EMA, and other regulatory guidelines.
• Academic & Industrial R&D: A valuable tool for chemists and biologists in universities and corporate R&D departments exploring new antimicrobial therapies.

Basic Information

Product Name	Epi-Doxycycline
CAS No.	3219-99-6
Molecular Formula	C₂₂H₂₄N₂O₈
Molecular Weight	444.44 g/mol
Synonyms	4-Epidoxycycline; (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide; Doxycycline Impurity C; Doxycycline EP Impurity C; Doxycycline Related Compound C; 4-Epi-doxycycline hydrate; Antibiotic XR-586
EINECS	Contact for details

Quality Control

Our Epi-Doxycycline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.