Description

Linoleic Acid-1-14C is a carbon-14 radiolabeled form of the essential ω-6 fatty acid, linoleic acid, where the radioactive isotope is specifically located at the C-1 carboxyl carbon. This compound is a critical tool for metabolic and pharmacokinetic studies, enabling precise tracking of fatty acid absorption, distribution, metabolism, and excretion (ADME) in biological systems. It is primarily utilized by researchers and scientists in the pharmaceutical, nutritional science, and biochemical industries for tracer studies, lipid metabolism research, and drug development programs.

Application

• Metabolic Tracer Studies: Used to investigate the metabolic fate, β-oxidation, and incorporation into complex lipids of linoleic acid in vivo and in vitro.
• Drug Development & Pharmacokinetics (PK/ADME): Serves as a radiolabeled probe to study the absorption, distribution, metabolism, and excretion of fatty acid-based drug candidates or nutrients.
• Nutritional Biochemistry Research: Tracks the uptake and utilization of essential fatty acids in cell cultures, tissues, and whole organisms to understand dietary impacts.
• Lipidomics and Biochemical Pathway Analysis: Elucidates biosynthetic pathways for eicosanoids, prostaglandins, and other bioactive lipid mediators derived from linoleic acid.
• Environmental & Agricultural Fate Studies: Monitors the degradation and environmental persistence of fatty acids and related compounds.

Basic Information

Product Name	Linoleic Acid-1-14C
CAS No.	3131-66-6
Molecular Formula	C18H32O2 (with 14C at C-1)
Molecular Weight	~280.45 g/mol (specific activity dependent)
Synonyms	(9Z,12Z)-Octadeca-9,12-dienoic-1-14C acid; Radiolabeled Linoleic Acid; [1-14C]-Linoleic Acid; cis,cis-9,12-Octadecadienoic-1-14C Acid; 9,12-Linoleic-1-14C Acid; LA-1-14C; 14C-Linoleic Acid; Essential Fatty Acid-1-14C
EINECS	221-470-5 (for unlabeled linoleic acid)

Quality Control

Every batch of Linoleic Acid-1-14C is manufactured and analyzed under strict quality control protocols to ensure radiochemical purity, chemical purity, and specific activity meet the stringent requirements of research applications. Comprehensive Certificates of Analysis (COA) are provided, detailing results for key parameters including radiochemical purity (by HPLC or TLC), specific activity, and chemical identity (by IR, NMR). Our quality system ensures traceability and consistency for reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent (as specified) under an inert atmosphere such as argon or nitrogen to minimize oxidation and radiolytic decomposition. Keep away from strong acids and organic solvents. For long-term stability, avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (IR/NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent	Toluene, Ethanol, or as specified
Concentration	0.1 mCi/mL (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.