Description

Ginkgotoxin Hydrochloride is a high-purity, isolated alkaloid derivative, specifically the hydrochloride salt form of ginkgotoxin (4'-O-methylpyridoxine). This compound is of significant interest for its role as a reference standard and a critical starting material in advanced research and development. It is essential for scientists and quality control professionals requiring precise analytical benchmarks. Primary applications include use in pharmaceutical research, toxicological studies, and the development of analytical methods for the quality control of Ginkgo biloba extracts and related products.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the identification and quantification of ginkgotoxin in raw materials and finished products.
• Toxicology and Safety Research: Used in studies investigating the anti-vitamin B6 activity and neurotoxic potential associated with Ginkgo biloba seeds and unprocessed extracts.
• Analytical Method Development: A critical component for developing and validating HPLC, LC-MS, and other chromatographic methods for impurity profiling.
• Dietary Supplement Quality Control: Employed by manufacturers to test and ensure the absence or controlled levels of this compound in commercial Ginkgo biloba leaf extracts.
• Academic and Biomedical Research: Facilitates biochemical studies on pyridoxine metabolism and the mechanism of action of vitamin B6 antagonists.
• Chemical Synthesis Intermediate: Acts as a key building block for the synthesis of novel analogs and derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Ginkgotoxin Hydrochloride
CAS No.	3131-27-9
Molecular Formula	C9H14ClNO3
Molecular Weight	219.66 g/mol
Synonyms	4'-O-Methylpyridoxine Hydrochloride; 5-(Hydroxymethyl)-4-(methoxymethyl)-2-methylpyridin-3-ol Hydrochloride; Ginkgotoxin HCl; MPN Hydrochloride; Vitamin B6 Antagonist Hydrochloride; 3-Hydroxy-5-(hydroxymethyl)-4-(methoxymethyl)-2-methylpyridine Hydrochloride
EINECS	221-518-5

Quality Control

Our Ginkgotoxin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against our stringent internal specifications. For research requiring official pharmacopeial standards, please contact our sales team for availability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.