Description

(16α)-9-Fluoro-16,17,21-Trihydroxy-Pregna-1,4-Diene-3,11,20-Trione CAS NO 3107-69-5 is a high-purity synthetic steroid derivative, also known as Triamcinolone, valued for its potent anti-inflammatory and immunosuppressive properties. This compound is a critical active pharmaceutical ingredient (API) and a key intermediate in the synthesis of advanced corticosteroid medications. It is essential for pharmaceutical manufacturers and research institutions developing treatments for dermatological conditions, allergic disorders, and autoimmune diseases, where precise chemical structure and purity are paramount for efficacy and safety.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of topical creams, ointments, and injectable solutions for potent corticosteroid therapies.
• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of Triamcinolone acetonide and other related corticosteroid derivatives.
• Dermatological Preparations: Used in medications for treating severe eczema, psoriasis, contact dermatitis, and other inflammatory skin conditions.
• Ophthalmic Solutions: Key component in eye drops and ointments for managing inflammatory eye diseases.
• Research & Development: Serves as a reference standard and starting material in pharmacological research for studying glucocorticoid receptor activity.
• Veterinary Medicine: Employed in anti-inflammatory and anti-pruritic treatments for animals.

Basic Information

Item	Details
Product Name	(16α)-9-Fluoro-16,17,21-Trihydroxy-Pregna-1,4-Diene-3,11,20-Trione
CAS No.	3107-69-5
Molecular Formula	C21H25FO6
Molecular Weight	392.42 g/mol
Synonyms	Triamcinolone; 9α-Fluoro-16α-hydroxyprednisolone; 9α-Fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione; Aristocort; Kenacort; Volon; Fluoxyprednisolone; 1,4-Pregnadiene-9α-fluoro-11β,16α,17α,21-tetrol-3,20-dione
EINECS	221-467-6

Quality Control

Our (16α)-9-Fluoro-16,17,21-Trihydroxy-Pregna-1,4-Diene-3,11,20-Trione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided with every shipment, detailing compliance with in-house specifications aligned with ICH guidelines. We support audits and can tailor quality parameters to meet specific pharmacopoeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.