Description

n-[(Benzyloxy)Carbonyl]-L-Phenylalanine Pentachlorophenyl Ester is a specialized amino acid derivative and activated ester used as a key building block in peptide synthesis. This compound matters for its role as a coupling reagent, enabling the efficient formation of peptide bonds under controlled conditions while protecting the amino functionality. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules.

Application

• Peptide Synthesis: Acts as a protected and activated amino acid derivative for solid-phase and solution-phase peptide coupling.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial labs for studying protein-protein interactions and enzyme mechanisms.
• Proteomics & Labeling: Employed in the preparation of modified peptides for mass spectrometry analysis and fluorescent labeling studies.
• Combinatorial Chemistry: A valuable reagent in the generation of diverse peptide libraries for drug discovery screening.

Basic Information

Product Name	n-[(Benzyloxy)Carbonyl]-L-Phenylalanine Pentachlorophenyl Ester
CAS No.	3086-21-3
Molecular Formula	C23H16Cl5NO4
Molecular Weight	541.64 g/mol
Synonyms	Z-Phe-OPcp; Z-L-Phenylalanine pentachlorophenyl ester; Cbz-Phe-OPcp; N-Carbobenzoxy-L-phenylalanine pentachlorophenyl ester; Nα-(Benzyloxycarbonyl)-L-phenylalanine 2,3,4,5,6-pentachlorophenyl ester; Z-Phenylalanine pentachlorophenyl ester; N-Cbz-L-phenylalanine pentachlorophenyl ester; Benzyloxycarbonylphenylalanine pentachlorophenyl ester
EINECS	221-400-6

Quality Control

Our n-[(Benzyloxy)Carbonyl]-L-Phenylalanine Pentachlorophenyl Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. All products undergo rigorous analytical testing, including HPLC and NMR, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-15.0° to -18.0° (c=1 in DMF)
Melting Point	158°C - 162°C
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.