Description

6Beta-Hydroxycortisol is a significant metabolite of cortisol, offering a crucial reference standard for biochemical research and diagnostic applications. This compound is essential for studying steroid metabolism, enzyme activity, and endocrine function. It is primarily utilized by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic institutions focused on endocrinology and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification of cortisol metabolites in drug metabolism and pharmacokinetic (DMPK) studies.
• Clinical Diagnostics: Used in the development and calibration of immunoassays and LC-MS/MS methods for measuring cortisol and related steroids in patient samples.
• Biochemical Research: A key tool for investigating the 6β-hydroxylation pathway of cortisol, relevant to cytochrome P450 enzyme function (particularly CYP3A4).
• Endocrinology Studies: Employed in research on adrenal gland function, stress response, and disorders like Cushing's syndrome.
• Analytical Method Development: Acts as a critical component for validating chromatographic separation and detection techniques for steroid analysis.
• Quality Control: Used in-house by manufacturers to ensure the accuracy and consistency of diagnostic kits and pharmaceutical ingredients.

Basic Information

Product Name	6Beta-Hydroxycortisol
CAS No.	3078-34-0
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	6β-Hydroxycortisol; 6β-Hydroxyhydrocortisone; 11β,17α,21-Trihydroxy-6β-pregn-4-ene-3,20-dione; (6β,11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione; Cortisol 6β-ol; 6β-OH-Cortisol
EINECS	Contact for details

Quality Control

Our 6Beta-Hydroxycortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.