Description

(2S)-2-[[5-Amino-1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Phosphonooxymethyl)Oxolan-2-Yl]Imidazole-4-Carbonyl]Amino]Butanedioic Acid is a high-purity nucleotide derivative and a key intermediate in the synthesis of complex biomolecules. This compound is critical for research and development in life sciences, particularly in the study of nucleotide metabolism and enzyme function. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on nucleotide chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside-based therapeutics, including antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolic pathways and kinase activity.
• Proteomics & Molecular Biology: Serves as a specialized reagent for modifying proteins or nucleic acids in advanced research applications.
• Diagnostic Reagent Development: Employed in the formulation of high-sensitivity assay kits for detecting specific enzymes or biomarkers.
• Academic Research: A valuable tool for universities and research institutes conducting fundamental studies in biochemistry and medicinal chemistry.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(2S)-2-[[5-Amino-1-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(Phosphonooxymethyl)Oxolan-2-Yl]Imidazole-4-Carbonyl]Amino]Butanedioic Acid
CAS No.	3031-95-6
Molecular Formula	C13H19N4O12P
Molecular Weight	454.28 g/mol
Synonyms	5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole Succinocarboxamide; AICAR Succinyl-CoA; SAICAR; (S)-2-(5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamido)succinic Acid; 5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)imidazole-4-carboxamide, N-succinyl-; 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxamide, Succino-; N-Succinyl-5-aminoimidazole-4-carboxamide-1-ribonucleotide; SAICAR (enzyme substrate).
EINECS	Contact for details

Quality Control

Our production of this nucleotide intermediate adheres to stringent quality protocols suitable for research and pharmaceutical applications. Each batch is characterized and tested to ensure high purity and structural integrity, with comprehensive analysis via HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (Enzymatic Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.