Description

Bucladesine CAS NO 362-74-3 is a cell-permeable cyclic adenosine monophosphate (cAMP) analog, widely recognized for its role as a potent activator of protein kinase A (PKA). This compound is crucial for fundamental biochemical research, enabling the study of intracellular signaling pathways, gene expression, and cellular differentiation. It is an essential research tool for pharmaceutical R&D, biotechnology, and academic institutions focused on cardiology, neurology, and oncology.

Application

• Biochemical Research: A key tool for studying cAMP-dependent signal transduction pathways and PKA activation in cell-based assays.
• Pharmaceutical Development: Used in preclinical research for investigating therapeutic targets related to heart function, neuronal protection, and cancer cell regulation.
• Cell Biology Studies: Employed to induce cellular differentiation, modulate ion channel activity, and examine the effects on cellular metabolism and apoptosis.
• Enzyme Kinetics: Serves as a stable substrate or activator in enzymatic studies involving kinases and phosphodiesterases.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Bucladesine
CAS No.	362-74-3
Molecular Formula	C18H24N5O8P
Molecular Weight	469.39 g/mol
Synonyms	Dibutyryl-cAMP; N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate; Dibutyryl cyclic AMP; DBcAMP; Bucladesine sodium; Bt2cAMP; DC2797
EINECS	206-650-1

Quality Control

Our Bucladesine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.