Description

4-Chloro-3-Fluoronitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), especially those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the chloro and fluoro substituents enhance biological activity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex, high-performance organic dyes and pigments.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and halogen groups make it an excellent candidate for nucleophilic substitution reactions to introduce various functional groups.

Basic Information

Product Name	4-Chloro-3-Fluoronitrobenzene
CAS No.	350-31-2
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-4-fluoro-2-nitrobenzene; 4-Chloro-3-fluoronitrobenzene; 2-Nitro-4-chlorofluorobenzene; 3-Fluoro-4-chloronitrobenzene; 4-Fluoro-3-chloronitrobenzene; Benzene, 1-chloro-4-fluoro-2-nitro-; 350-31-2; NSC 406106
EINECS	206-496-5

Quality Control

Our 4-Chloro-3-Fluoronitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.