Description

Phosphoribosyl-n-Formylglycineamide is a key biochemical intermediate in the *de novo* purine biosynthesis pathway. This compound matters for its critical role in the production of nucleotides, which are fundamental building blocks for DNA, RNA, and various coenzymes. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for biochemical research, enzymatic studies, and the development of nucleotide-based therapeutics.

Application

• Biochemical Research: Essential substrate for studying the enzymatic mechanisms of the purine biosynthesis pathway, particularly phosphoribosylformylglycinamidine synthase (FGAM synthase).
• Enzyme Kinetics & Inhibition Studies: Used to investigate enzyme activity, kinetics, and to screen for potential inhibitors targeting nucleotide synthesis for therapeutic applications.
• Nucleotide Synthesis: Serves as a critical precursor in the multi-step synthesis of inosine monophosphate (IMP) and other purine nucleotides.
• Metabolic Pathway Analysis: A tool for tracing and analyzing metabolic fluxes in cellular systems, particularly in cancer research where purine metabolism is often dysregulated.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, or NMR for qualitative and quantitative analysis in complex biological matrices.
• Academic & Pharmaceutical R&D: Supports fundamental research in molecular biology and the development of novel drugs that interfere with purine metabolism, such as anticancer or antimicrobial agents.

Basic Information

Product Name	Phosphoribosyl-n-Formylglycineamide
CAS No.	349-34-8
Molecular Formula	C8H15N2O9P
Molecular Weight	314.19 g/mol
Synonyms	5'-Phosphoribosyl-N-formylglycinamide; FGAR; Formylglycinamide ribonucleotide; N-Formylglycinamide ribotide; 5'-O-Phosphono-D-ribofuranosyl)formamide; (2R,3S,4R,5R)-5-(Formamidomethyl)-2,3,4-trihydroxyoxolan-2-yl]methyl dihydrogen phosphate; 5'-Phosphoribosyl-N-formylglycinamide; α-N-Formylglycinamide ribonucleotide
EINECS	Contact for details

Quality Control

Our Phosphoribosyl-n-Formylglycineamide is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for sensitive biochemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.