Description

Harmaline is a naturally occurring β-carboline alkaloid and a key reference standard in analytical chemistry and life science research. Its unique structure makes it a valuable tool for studying neurological pathways and enzyme inhibition mechanisms. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors who require reliable, well-characterized materials for method development and biochemical studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of related pharmaceutical compounds and herbal extracts.
• Biochemical Research: Serves as a selective, reversible inhibitor of monoamine oxidase A (MAO-A) in enzymatic studies and neurological research.
• Analytical Chemistry: Employed as a primary standard for calibrating HPLC, LC-MS, and other chromatographic systems in quality control laboratories.
• Neuroscience Studies: Utilized in preclinical research to investigate its effects on serotonin receptors and other central nervous system targets.
• Natural Product Isolation & Analysis: Acts as a marker compound for the standardization and authentication of botanicals like Peganum harmala (Syrian Rue).
• Chemical Synthesis: Used as a precursor or intermediate in the synthesis of more complex β-carboline derivatives for medicinal chemistry programs.

Basic Information

Product Name	Harmaline
CAS No.	304-21-2
Molecular Formula	C13H14N2O
Molecular Weight	214.26 g/mol
Synonyms	3,4-Dihydroharmine; 4,9-Dihydro-7-methoxy-1-methyl-3H-pyrido[3,4-b]indole; Dihydroharmine; Harmidine; O-Methyl-dihydroharmol; NSC 33638; Armaline
EINECS	206-161-8

Quality Control

Our Harmaline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We support compliance with cGMP and ISO guidelines for research and pharmaceutical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.