Description

Cyclizine Hydrochloride is a high-purity pharmaceutical active ingredient (API) and fine chemical intermediate. It is a piperazine derivative with significant commercial value in the synthesis of antiemetic and antihistamine medications. This compound is essential for manufacturers in the pharmaceutical and life sciences sectors requiring reliable, high-quality raw materials for formulation and research. Its consistent performance is critical for ensuring the efficacy and safety of final drug products.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in antiemetic and antivertigo medications.
• Antihistamine Formulations: Used in the development and production of drugs targeting motion sickness and nausea.
• Chemical Intermediate: Serves as a crucial building block in the organic synthesis of more complex pharmaceutical compounds.
• Research & Development: Utilized in preclinical and clinical studies within academic and industrial laboratories.
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method development in pharmacopeial testing.

Basic Information

Product Name	Cyclizine Hydrochloride
CAS No.	303-25-3
Molecular Formula	C18H22N2·HCl
Molecular Weight	302.84 g/mol
Synonyms	1-(Diphenylmethyl)-4-methylpiperazine hydrochloride; Marzine Hydrochloride; N-Benzhydryl-N'-methylpiperazine Hydrochloride; N-Methyl-4-benzhydrylpiperazine Hydrochloride; Cyclizine HCl; 1-Benzhydryl-4-methylpiperazine Hydrochloride; EINECS 206-137-3
EINECS	206-137-3

Quality Control

Our Cyclizine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, residual solvents, and heavy metals to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.