Description

Dbco-Peg24-Nhs Ester is a heterobifunctional crosslinker featuring a DBCO (dibenzocyclooctyne) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and an NHS ester for efficient amine coupling. This compound is essential for creating stable, site-specific bioconjugates without the need for cytotoxic copper catalysts, enabling advanced research and development. It is primarily used by scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and the synthesis of functionalized nanoparticles and biomaterials.

Application

• Bioconjugation and ADC Development: Site-specific labeling of antibodies, proteins, and peptides for therapeutic and diagnostic applications.
• Biomaterial Functionalization: Modification of hydrogels, surfaces, and nanoparticles with bioactive ligands for cell culture and drug delivery systems.
• Click Chemistry Reagent: A critical reagent for copper-free click chemistry reactions, facilitating the modular assembly of complex molecular architectures.
• Proteomics Research: Crosslinking agent for studying protein-protein interactions and mapping protein networks.
• Diagnostic Assay Development: Conjugation of detection molecules (e.g., fluorophores, enzymes) to antibodies or oligonucleotides for ELISA, lateral flow, and other assays.
• Polymer Chemistry: Building block for synthesizing functionalized PEG-based polymers and dendrimers with precise chemical handles.

Basic Information

Product Name	Dbco-Peg24-Nhs Ester
CAS No.	2765066-38-2
Molecular Formula	C73H116N2O28
Molecular Weight	~1469.7 g/mol
Synonyms	DBCO-PEG24-NHS Ester; DBCO-PEG24-NHS; Dibenzocyclooctyne-PEG24-N-hydroxysuccinimide Ester; DBCO-PEG24-NHS Ester; 1-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-tetracosaoxa-75-azaoctaheptacontan-78-one 2,5-Dioxopyrrolidin-1-yl Ester; DBCO-PEG24-OSu; Azadibenzocyclooctyne-PEG24-NHS Ester
EINECS	Contact for details

Quality Control

Our Dbco-Peg24-Nhs Ester is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency for critical research and production. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional performance is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Activity (DBCO)	≥ 90%
Functional Activity (NHS Ester)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.