Description

Dbco-Peg24-Acid CAS NO 2765066-36-0 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a terminal carboxylic acid for further conjugation via amide bond formation. This compound is critical for creating stable, well-defined bioconjugates and advanced materials without the need for cytotoxic copper catalysts. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the precise construction of drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• ADC (Antibody-Drug Conjugate) Linker: Facilitates the stable, site-specific conjugation of cytotoxic payloads to monoclonal antibodies for targeted cancer therapy.
• PEGylation Reagent: Used to modify peptides, proteins, and nanoparticles to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Synthesis: Enables the labeling of biomolecules (antibodies, oligonucleotides) with fluorophores or other reporter molecules for imaging and detection assays.
• Hydrogel and Biomaterial Crosslinking: Serves as a functional crosslinker to create biocompatible networks with tailored properties for tissue engineering and 3D cell culture.
• Surface Functionalization: Used to create bio-inert or bioactive coatings on sensors, chips, and medical devices via the DBCO "click" chemistry handle.
• Small Molecule Prodrug Development: Allows for the controlled attachment of therapeutic agents to targeting ligands or solubility-enhancing PEG chains.
• Oligonucleotide Conjugation: Enables the stable attachment of siRNA, aptamers, or other oligonucleotides to delivery vehicles or solid supports.

Basic Information

Item	Detail
Product Name	Dbco-Peg24-Acid
CAS No.	2765066-36-0
Molecular Formula	CnHmN2O26 (Contact for exact formula)
Molecular Weight	~1500 g/mol (Contact for exact weight)
Synonyms	DBCO-PEG24-COOH; DBCO-PEG24-Acid; Dibenzocyclooctyne-PEG24-Acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71-tetraoxaheptatetracont-73-yl)carbamate; Azadibenzocyclooctyne-PEG24-Acid; ADIBO-PEG24-Acid; DBCO-PEG24-Carboxylic Acid; DBCO-PEG24-NHS Ester Precursor
EINECS	Contact for details

Quality Control

Our Dbco-Peg24-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for critical bioconjugation applications. Certificates of Analysis (COA) are provided, detailing specifications for identity, purity, and functional integrity. We support compliance with relevant GMP and ISO 9001 standards for research and pharmaceutical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
DBCO Functional Assay	≥ 90%
Acid Value (Titration)	Contact for details
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.