Description

Clevidipine-D7 CAS NO 2747918-66-5 is a deuterated isotopologue of the short-acting dihydropyridine calcium channel blocker, clevidipine. This stable isotope-labeled compound is essential for conducting precise pharmacokinetic and metabolic studies, providing an internal standard for accurate quantification via mass spectrometry. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists focused on bioanalytical method development and drug metabolism research.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a high-purity, non-interfering internal standard for the quantitative bioanalysis of clevidipine in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate sensitive and specific analytical methods for clevidipine quantification, ensuring regulatory compliance.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Pharmaceutical Quality Control and Impurity Testing: Can be utilized as a reference standard in the impurity profiling and stability testing of clevidipine drug substances and products.
• Clinical Research Support: Facilitates reliable therapeutic drug monitoring and pharmacokinetic modeling in clinical trials for hypertensive emergencies and perioperative hypertension.

Basic Information

Product Name	Clevidipine-D7
CAS No.	2747918-66-5
Molecular Formula	C21H16D7Cl2NO6
Molecular Weight	456.34 g/mol (approx.)
Synonyms	4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester-D7; Clevidipine (phenyl-D7); Cleviprex-D7; H 324/38-D7; (4R/S)-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl (1-methylethyl) ester-D7; Stable Isotope Labeled Clevidipine; Clevidipine-d7
EINECS	Contact for details

Quality Control

Our Clevidipine-D7 is manufactured under strict quality control protocols to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Incorporation)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.