Description

Bis-Peg25-Tfp Ester is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal tetrafluorophenyl (TFP) ester group. This reactive ester group is designed for efficient, amine-selective conjugation under mild aqueous conditions, making it a critical reagent for bioconjugation and linker chemistry. It is essential for researchers and manufacturers in pharmaceutical development, biotech, and advanced material science who require reliable, water-soluble crosslinkers for creating stable PEGylated constructs, drug conjugates, and functionalized surfaces.

Application

• Bioconjugation and PEGylation: Site-specific coupling of peptides, proteins, or antibodies to other biomolecules, nanoparticles, or solid supports.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: Serving as a hydrophilic, cleavable or non-cleavable spacer to connect cytotoxic payloads to targeting antibodies.
• Hydrogel and Biomaterial Functionalization: Introducing reactive handles into polymer networks for subsequent immobilization of bioactive molecules.
• Diagnostic Reagent Preparation: Conjugating fluorophores, enzymes, or other labels to proteins for use in immunoassays and biosensors.
• Surface Modification: Creating non-fouling, biocompatible coatings on medical devices or sensor chips with available amine groups for further coupling.
• Drug Delivery System Development: Constructing sophisticated nanocarriers (e.g., liposomes, polymeric micelles) with targeted release capabilities.

Basic Information

Product Name	Bis-Peg25-Tfp Ester
CAS No.	2567199-52-2
Molecular Formula	Contact for details
Molecular Weight	~1300 g/mol (Average)
Synonyms	Bis-PEG25-TFP Ester; α,ω-Bis-Tetrafluorophenyl Ester of PEG25; Poly(ethylene glycol) bis(2,3,5,6-tetrafluorophenyl) succinate (n~25); Heterobifunctional PEG-TFP Ester; TFP-PEG25-TFP; Tetrafluorophenyl-PEG25-Tetrafluorophenyl Ester; PEG25 Ditetrafluorophenyl Succinate; Reactive PEG Crosslinker
EINECS	Contact for details

Quality Control

Our Bis-Peg25-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and functional group analysis, to ensure consistency and performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your GMP, ISO, or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Average Molecular Weight	1200 - 1400 g/mol
Functional Group Assay (TFP Ester)	≥ 90% of theoretical
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.