Description

Amino-Peg24-Acid is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine and a carboxylic acid group separated by a 24-unit PEG spacer. This compound is a critical building block for creating stable, hydrophilic, and biocompatible linkers in advanced bioconjugation and nanotechnology applications. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and materials science sectors who require precise and reproducible spacer molecules for drug delivery systems, surface functionalization, and cross-linking.

Application

• Bioconjugation & Drug Delivery: Serves as a versatile linker for attaching targeting ligands, drugs, or imaging agents to nanoparticles, proteins, or antibodies, enhancing solubility and circulation time.
• Surface Modification: Used to functionalize solid surfaces (e.g., gold, silica, polymers) with amine or carboxyl groups for subsequent biomolecule immobilization in biosensor and microarray development.
• Hydrogel & Biomaterial Synthesis: Acts as a cross-linking agent or functional monomer to create PEG-based hydrogels with tailored mechanical properties and bioactivity for tissue engineering.
• Diagnostic Reagent Preparation: Employed in the synthesis of enzyme conjugates, fluorescent probes, and other diagnostic reagents where a long, flexible, and non-immunogenic spacer is required.
• Peptide & Protein Modification: Facilitates site-specific PEGylation (pegylation) of peptides and proteins to improve stability, reduce immunogenicity, and modulate pharmacokinetics.
• Lipid Nanoparticle (LNP) Formulation: Incorporated into lipid formulations to provide functional handles for surface PEGylation, crucial for modern mRNA and siRNA delivery systems.

Basic Information

Product Name	Amino-Peg24-Acid
CAS No.	2563873-76-5
Molecular Formula	C52H105NO26 (Typical for 24 EO units)
Molecular Weight	~1159.4 g/mol (Theoretical average)
Synonyms	NH2-PEG24-COOH; α-Amino-ω-carboxy-tetraicosa(ethylene glycol); 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71-Tetracosaoxaheptatricontanedioic acid, 73-amino-; Amine-PEG24-acid; H2N-PEG24-COOH; Amino-Polyethylene glycol24-Acid; Heterobifunctional PEG 24, amine and acid
EINECS	Contact for details

Quality Control

Every batch of Amino-Peg24-Acid is manufactured under strict quality management protocols. We employ advanced analytical techniques including NMR, HPLC, and mass spectrometry to verify identity, purity, and functional group integrity. Our products are designed to meet the stringent requirements of research and cGMP manufacturing environments. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Assay (Functional Groups)	≥ 90% (by titration/NMR)
Molecular Weight Distribution (SEC/GPC)	PDI ≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.