Description

Uridine, 4-Oxime, 5'-(2-Methylpropanoate), (4E)- is a chemically modified nucleoside derivative, specifically a protected oxime ester of uridine. This compound is of significant value as a key synthetic intermediate or building block in advanced organic and medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel nucleoside-based therapeutics, prodrugs, or biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral or anticancer nucleoside analogs.
• Prodrug Development: Used in research to create prodrug forms of nucleoside-based active pharmaceutical ingredients (APIs) to enhance bioavailability or targeting.
• Biochemical Research: Acts as a modified substrate or inhibitor in enzymatic studies related to nucleotide metabolism and nucleic acid processing.
• Organic Synthesis Building Block: Provides a protected, reactive handle for further chemical modifications on the nucleoside scaffold for library synthesis.
• Labeled Compound Synthesis: Potential starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing studies.

Basic Information

Product Name	Uridine, 4-Oxime, 5'-(2-Methylpropanoate), (4E)-
CAS No.	2492423-30-8
Molecular Formula	C13H17N3O7
Molecular Weight	327.29 g/mol
Synonyms	(4E)-Uridine-4-oxime 5'-(2-methylpropanoate); 5'-O-Isobutyryl-4-oximino-uridine; 4-Oximino-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-((2-methylpropanoyloxy)methyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 4-(Hydroxyimino)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-((isobutyryloxy)methyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 4-Oximinouridine 5'-isobutyrate; (E)-4-(Hydroxyimino)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-((isobutyryloxy)methyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our Uridine, 4-Oxime, 5'-(2-Methylpropanoate), (4E)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; it is recommended to handle and store it under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.