Description

4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxanonatriacontanoic Acid, 39-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)- is a specialized functionalized polyethylene glycol (PEG) derivative featuring a terminal maleimide group. This compound is engineered to serve as a critical heterobifunctional crosslinker, enabling the site-specific conjugation of biomolecules and polymers under mild aqueous conditions. It is essential for researchers and manufacturers in the fields of bioconjugation, advanced drug delivery systems, and polymer chemistry who require precise and stable linkages.

Application

• Bioconjugation and ADC Development: Site-specific coupling of antibodies, proteins, or peptides to drugs, toxins, or imaging agents via thiol-maleimide chemistry for antibody-drug conjugates (ADCs) and diagnostic probes.
• PEGylation and Drug Delivery: Functionalization of nanoparticles, liposomes, and therapeutic proteins with stealth PEG chains to improve pharmacokinetics, solubility, and stability.
• Hydrogel and Biomaterial Synthesis: Crosslinking agent for creating biocompatible hydrogels and scaffolds with tailored mechanical properties for tissue engineering and controlled release applications.
• Surface Modification: Immobilization of biomolecules onto sensor chips, microarrays, and other solid supports for biosensing and diagnostic platforms.
• Polymer Chemistry: Building block for synthesizing complex block copolymers and functionalized polymers with precise architectures.

Basic Information

Item	Detail
Product Name	4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxanonatriacontanoic Acid, 39-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-
CAS No.	2445165-75-1
Molecular Formula	C₃₉H₆₉NO₁₅
Molecular Weight	816.0 g/mol (Contact for details)
Synonyms	Maleimide-PEG12-acid; MAL-PEG12-COOH; α-Maleimido-ω-carboxy PEG (MW ~800); 1-[39-Carboxy-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontyl]-1H-pyrrole-2,5-dione; Heterobifunctional PEG linker, Maleimide-PEG-Acid; NHS ester precursor; PEG-based crosslinker
EINECS	Contact for details

Quality Control

Every batch of our Maleimide-PEG-Acid is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure batch-to-batch consistency and high purity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity (HPLC), identity confirmation (NMR, MS), and functional group validation. Our quality protocols are designed to meet the stringent requirements of research and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Functional Groups)	≥ 90% (Maleimide, Acid)
Water Content (KF)	≤ 1.0%
Molecular Weight Distribution	PDI ≤ 1.05 (by GPC)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.