Description

Mal-Peg12-Dspe is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a DSPE phospholipid, connected by a 12-unit PEG spacer. This compound is engineered for the site-specific conjugation of thiol-containing molecules, such as peptides, proteins, or antibodies, to lipid-based delivery systems like liposomes and micelles. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors, enabling the development of targeted drug delivery platforms, diagnostic imaging agents, and advanced nanomedicines.

Application

• Liposome Functionalization: Conjugation of targeting ligands (e.g., antibodies, peptides) to the surface of stealth or conventional liposomes for active drug targeting.
• Nanoparticle PEGylation: Introduction of a reactive maleimide handle onto lipid nanoparticles (LNPs) or polymeric micelles for subsequent coupling of biomolecules.
• Antibody-Drug Conjugate (ADC) Linker: Serving as a component in the construction of complex ADC architectures that utilize lipid carriers.
• Diagnostic Probe Synthesis: Labeling of lipid vesicles with contrast agents or fluorescent dyes for imaging applications.
• Membrane Protein Studies: Modification of lipid bilayers or proteoliposomes for biophysical and biochemical research.
• Surface Modification: Creating biofunctionalized surfaces on lipid-coated sensors or chips.

Basic Information

Product Name	Mal-Peg12-Dspe
CAS No.	2413909-83-6
Molecular Formula	C95H180N2O49P
Molecular Weight	~1981.5 g/mol
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]; DSPE-PEG(2000)-Maleimide; Maleimide-PEG12-DSPE; 1,2-Dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]amide terminated with maleimide; DSPE-PEG12-Mal; Mal-PEG12-DSPE; DSPE-PEG2000-Maleimide; N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycerol-3-phosphoethanolamine maleimide
EINECS	Contact for details

Quality Control

Our Mal-Peg12-Dspe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. Specifications are aligned with standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), functional group substitution ratio, and critical physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Maleimide Substitution	≥ 90%
Molecular Weight (MS)	1900 - 2100 Da
Solubility	Soluble in chloroform, DMSO, DMF; partially soluble in ethanol
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.