Description

3-Azabicyclo[3.1.0]Hexane-2,3-Dicarboxylic Acid, 6,6-Dimethyl-, 3-(9H-Fluoren-9-Ylmethyl) Ester, (1R,2S,5S)- is a high-purity, stereochemically defined bicyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, three-dimensional scaffold that is essential for constructing complex molecules with precise spatial orientation. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, especially for neurological disorders.
• Peptidomimetics Design: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Employed as a building block in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and lead optimization campaigns for drug discovery.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and protein-protein interactions.
• Academic Research: Serves as a valuable substrate for methodological development in organic and synthetic chemistry.

Basic Information

Product Name	3-Azabicyclo[3.1.0]Hexane-2,3-Dicarboxylic Acid, 6,6-Dimethyl-, 3-(9H-Fluoren-9-Ylmethyl) Ester, (1R,2S,5S)-
CAS No.	2413059-77-3
Molecular Formula	C24H25NO4
Molecular Weight	391.46 g/mol
Synonyms	(1R,2S,5S)-6,6-Dimethyl-3-(9H-fluoren-9-ylmethyl) 3-azabicyclo[3.1.0]hexane-2,3-dicarboxylate; Fmoc-Protected 3-Azabicyclo[3.1.0]hexane Amino Acid Derivative; (1R,2S,5S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic Acid; Fmoc-DMABH; Chiral Bicyclic Proline Analogue; Rigid Proline Mimetic; Stereoisomerically Pure Azabicyclohexane Ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Identity and purity are confirmed through a suite of analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.