Description

Thalidomide-o-Peg4-Boc CAS NO 2411681-87-1 is a high-purity, functionalized chemical intermediate designed for advanced pharmaceutical and bioconjugation research. This compound is critical for the precise construction of PROTACs (Proteolysis Targeting Chimeras) and other bifunctional molecules, enabling targeted protein degradation. It is primarily utilized by research institutions, pharmaceutical R&D departments, and CROs (Contract Research Organizations) developing next-generation therapeutics.

Application

• PROTAC Linker Synthesis: Serves as a key building block for constructing the linker region in Proteolysis Targeting Chimeras, connecting the E3 ligase ligand to the target protein binder.
• Bioconjugation & ADC Development: Used in the site-specific modification of antibodies, proteins, and peptides for creating Antibody-Drug Conjugates (ADCs) and other targeted delivery systems.
• Chemical Biology Probes: Enables the development of molecular probes for studying protein function, localization, and interaction networks within cells.
• Pharmaceutical Intermediate: Acts as a critical synthetic intermediate in the multi-step synthesis of novel small molecule drug candidates with enhanced pharmacokinetic properties.
• Polyethylene Glycol (PEG) Modification: The integrated PEG4 spacer improves solubility and reduces immunogenicity, making it valuable for optimizing drug-like properties.

Basic Information

Product Name	Thalidomide-o-Peg4-Boc
CAS No.	2411681-87-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Boc-4-((2-(2-(2-(2-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl)piperazine; Thalidomide-PEG4-t-butyloxycarbonyl; Boc-PEG4-Thalidomide; (2,6-Dioxo-3-piperidyl)-PEG4-Boc; PROTAC Linker for Cereblon; E3 Ligase Ligand-PEG4-Boc; Thalidomide-O-(CH2CH2O)4-Boc
EINECS	Contact for details

Quality Control

Our Thalidomide-o-Peg4-Boc is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development under cGMP guidelines for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.