Description

Propargyl-Peg12-Bromide is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group and a terminal bromide, enabling orthogonal conjugation strategies in advanced material synthesis. This compound is essential for creating precisely engineered biomaterials, drug delivery systems, and functional surfaces through robust click chemistry and nucleophilic substitution reactions. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing next-generation therapeutics and diagnostic tools.

Application

• Functionalization of nanoparticles and surfaces for targeted drug delivery systems.
• Synthesis of antibody-drug conjugates (ADCs) and other bioconjugates via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Preparation of cross-linked hydrogels and polymeric networks for tissue engineering scaffolds.
• Modification of peptides, proteins, and oligonucleotides to introduce hydrophobic tags or imaging probes.
• Creation of functional initiators or monomers for controlled radical polymerization (e.g., ATRP).
• Development of biosensors and diagnostic assay components through surface immobilization.
• Production of specialized PEGylated lipids for lipid nanoparticle (LNP) formulation.
• Intermediate in the synthesis of complex dendrimers and multi-arm PEG derivatives.

Basic Information

Product Name	Propargyl-Peg12-Bromide
CAS No.	2410937-34-5
Molecular Formula	C31H59BrO12
Molecular Weight	703.70 g/mol
Synonyms	1-Bromo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxa-38-azaheptatriacont-37-yn-38-ium; Propargyl-PEG12-Br; α-Propargyl-ω-bromo-dodecaethylene glycol; Bromo-PEG12-propargyl; Propargyl terminated PEG bromide (n=12); 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxa-38-azaheptatriacont-37-yn-38-ium, 1-bromo-; Heterobifunctional PEG linker, Propargyl/Br; Propargyl-PEG12-alkyl bromide
EINECS	Contact for details

Quality Control

Our Propargyl-Peg12-Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and cGMP manufacturing. Comprehensive Certificates of Analysis (COA) detailing purity, moisture content, and functional group integrity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight Confirmation (MS)	Conforms (M+Na+ or M+H+)
Water Content (KF)	≤ 1.0%
Functional Group Analysis	≥ 90% for propargyl and bromide termini

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.