Description

Taurolithocholic Acid-D5 is a deuterated analog of the bile acid taurolithocholic acid, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is an essential tool for quantitative mass spectrometry, enabling precise internal standardization and accurate pharmacokinetic or metabolic studies. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors for advanced analytical applications.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of bile acids and their conjugates.
• Metabolic Pathway Research: Used in tracer studies to investigate the biosynthesis, metabolism, and enterohepatic circulation of bile acids.
• Drug Development & Pharmacokinetics: Enables accurate measurement of drug-induced changes in bile acid profiles and assessment of compound absorption and excretion.
• Clinical Diagnostics: Supports the development and validation of high-precision assays for detecting and quantifying bile acid disorders.
• Biomarker Discovery: Facilitates the identification and validation of bile acid-related biomarkers for various hepatic and gastrointestinal diseases.
• Quality Control & Method Validation: Essential for ensuring the accuracy, precision, and reliability of analytical methods in regulatory environments.

Basic Information

Item	Detail
Product Name	Taurolithocholic Acid-D5
CAS No.	2410279-97-7
Molecular Formula	C₂₆H₄₀D₅NO₆S
Molecular Weight	~507.7 g/mol
Synonyms	3α-Hydroxy-5β-cholan-24-oyltauro-D5-glycine; Taurine-conjugated Lithocholic Acid-D5; Taurolithocholate-D5; 3α-Hydroxy-5β-cholanic acid-24-taurine-D5; Deuterated Taurolithocholic Acid; TLCAD5; [D5]-Tauro-3α-hydroxy-5β-cholan-24-oic Acid; N-[(3α,5β)-3-Hydroxy-24-oxocholan-24-yl]-D5-taurine
EINECS	Contact for details

Quality Control

Every batch of Taurolithocholic Acid-D5 is produced and analyzed under strict quality management protocols to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuterium incorporation and chemical purity, ensuring compliance with research and analytical standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.