Description

Tauroursodeoxycholic Acid-D4 (Sodium Salt) is a deuterated sodium salt derivative of the bile acid tauroursodeoxycholic acid (TUDCA), specifically designed for use as a high-purity internal standard in analytical chemistry. This stable isotope-labeled compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise measurement of TUDCA and related metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the accurate bioanalysis of TUDCA in plasma, serum, and tissue samples.
• Metabolic Pathway Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to trace and quantify the metabolism and distribution of tauroursodeoxycholic acid.
• Pharmaceutical R&D: Supports drug development programs for hepatoprotective and neuroprotective agents where TUDCA is an active pharmaceutical ingredient (API) or a key metabolite.
• Clinical Research Assays: Enables the development and validation of robust clinical diagnostic assays for monitoring bile acid profiles in patients with liver disorders.
• Quality Control & Method Validation: Serves as a critical reference material in analytical method development, validation, and routine quality control to ensure data integrity and regulatory compliance (e.g., FDA, EMA guidelines).

Basic Information

Product Name	Tauroursodeoxycholic Acid-D4 (Sodium Salt)
CAS No.	2410279-95-5
Molecular Formula	C26H40D4NNaO6S
Molecular Weight	~521.7 g/mol
Synonyms	TUDCA-d4 Sodium Salt; Sodium Tauroursodeoxycholate-d4; 2-[[(3α,5β,7β,8ξ)-3,7-Dihydroxy-24-oxocholan-8-yl]amino]ethanesulfonate-d4 Sodium Salt; Ursodeoxycholyltaurine-d4 Sodium Salt; Taurodeuterated Ursodeoxycholic Acid Sodium Salt; Deuterated TUDCA Sodium; Tauroursodeoxycholic Acid (tetradeuterated) Sodium Salt
EINECS	Contact for details

Quality Control

Our Tauroursodeoxycholic Acid-D4 (Sodium Salt) is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (≥98% D), chemical purity (by HPLC), and identity confirmation. We adhere to industry best practices to support your compliance needs in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.