Description

Mal-Peg2-Vcp-Nb CAS NO 2395887-69-9 is a heterobifunctional crosslinker featuring a maleimide group and a vinyl carbonyl pyridine (Vcp) moiety, connected by a short, flexible polyethylene glycol (PEG2) spacer. This compound is engineered for precise, site-specific bioconjugation, enabling the stable attachment of biomolecules such as antibodies, peptides, or proteins to various surfaces, nanoparticles, or other biomolecules under mild, controlled conditions. It is an essential tool for researchers and developers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, diagnostic assay manufacturing, and advanced materials science.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies via the maleimide-thiol chemistry.
• Diagnostic Probe Conjugation: Immobilization of antibodies, antigens, or enzymes onto sensor surfaces, microplates, or magnetic beads for ELISA, lateral flow assays, and biosensors.
• Protein and Peptide Labeling: Site-specific modification of cysteine-containing proteins or peptides with fluorophores, biotin, or other functional tags.
• Nanoparticle Functionalization: Coating of quantum dots, liposomes, or polymeric nanoparticles with targeting ligands for therapeutic or imaging applications.
• Biomaterial Surface Modification: Creating bioactive surfaces on hydrogels, scaffolds, or medical devices to promote specific cellular interactions.
• Affinity Chromatography Resin Preparation: Covalent attachment of ligands to solid supports for protein purification.
• Chemical Biology Tool Development: Used in probe synthesis for studying protein-protein interactions or cellular localization.

Basic Information

Item	Detail
Product Name	Mal-Peg2-Vcp-Nb
CAS No.	2395887-69-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG2-Vinyl Carbonyl Pyridine-Norbornene; Heterobifunctional PEG Crosslinker, Mal-PEG2-VCP; VCP Crosslinking Reagent; Norbornene-PEG2-Maleimide; ADC Linker; Site-specific Bioconjugation Reagent; Maleimide PEG VCP Reagent
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Vcp-Nb is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.