Description

m-Peg24-Nhs Ester CAS NO 2395839-96-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring an amine-reactive N-hydroxysuccinimide (NHS) ester at one terminus. This compound is critical for creating stable, hydrophilic spacers in bioconjugation chemistry, significantly improving the solubility, stability, and pharmacokinetic profiles of modified biomolecules. It is an essential reagent for researchers and manufacturers in pharmaceutical development, diagnostics, and advanced material science who require precise and reliable PEGylation agents.

Application

• Biopharmaceutical PEGylation: Conjugation to therapeutic peptides, proteins, and antibodies to reduce immunogenicity, prolong circulation half-life, and enhance solubility.
• Diagnostic Probe Modification: Functionalization of antibodies, enzymes, or other detection molecules for use in immunoassays, biosensors, and imaging agents.
• Drug Delivery System Fabrication: Synthesis of functionalized linkers for nanoparticle surface modification, liposome conjugation, and polymer-drug conjugate synthesis.
• Biomaterial Surface Engineering: Creating non-fouling, hydrophilic coatings on medical devices, implants, and sensor surfaces to improve biocompatibility.
• Crosslinking and Immobilization: Covalent attachment of biomolecules to solid supports for chromatography, affinity purification, and microarray platforms.
• ADC (Antibody-Drug Conjugate) Linker Chemistry: Serving as a component in the design of cleavable or non-cleavable linkers for targeted cancer therapies.

Basic Information

Product Name	m-Peg24-Nhs Ester
CAS No.	2395839-96-8
Molecular Formula	C58H109NO28 (Typical for mPEG24-NHS)
Molecular Weight	~1244.5 g/mol (Theoretical Average)
Synonyms	mPEG24-NHS Ester; Methoxy-PEG24-NHS; α-Methoxy-ω-succinimidyl ester poly(ethylene glycol); NHS-PEG24-OMe; Succinimidyl ester of monomethoxy polyethylene glycol (MW ~1100); PEG24 NHS ester; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-tetracosaoxaoctaheptacontanoate; N-Hydroxysuccinimide ester of mPEG24
EINECS	Contact for details

Quality Control

Our m-Peg24-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) are provided, detailing specifications for purity, substitution efficiency, and critical impurities. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight (NMR)	1100 ± 50 Da
Degree of Substitution (NMR)	> 90%
Water Content (KF)	≤ 1.0%
Solubility	Clear, colorless solution in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.