Description

8-Benzyloxy-3’-Deoxyguanosine is a chemically modified nucleoside analog, specifically engineered for advanced research and pharmaceutical development. This compound serves as a critical synthetic intermediate and building block in the creation of novel oligonucleotides and prodrugs. It is primarily utilized by research scientists and process chemists in the fields of antiviral drug discovery, nucleic acid chemistry, and medicinal chemistry.

Application

• Antiviral Drug Development: Key intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or solid-support building block for creating antisense oligonucleotides and siRNA.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Prodrug Design: The benzyloxy group acts as a protective moiety, making it valuable in designing prodrugs with enhanced bioavailability.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate polymerase mechanisms.
• Chemical Biology: Useful for labeling and probing nucleic acid structures and interactions.

Basic Information

Item	Details
Product Name	8-Benzyloxy-3’-Deoxyguanosine
CAS No.	2389988-57-0
Molecular Formula	C₁₇H₁₉N₅O₄
Molecular Weight	357.36 g/mol
Synonyms	8-O-Benzyl-3'-deoxyguanosine; 3'-Deoxy-8-benzyloxyguanosine; 8-Benzyloxy-2'-deoxyguanosine (common misnomer); 8-BnO-3'-dG; Guanine, 9-[(2R,5S)-5-(hydroxymethyl)-2-tetrahydrofuranyl]-8-(phenylmethoxy)-; 8-Benzyloxy-3'-deoxy-Guanosine; 8-O-Benzyl-3'-deoxy-G; 3'-dG(Bn)
EINECS	Contact for details

Quality Control

Our 8-Benzyloxy-3’-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.