Description

Mal-Amido-Peg24-Tfp Ester is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group and a tetrafluorophenyl (TFP) ester. This compound is engineered for high-efficiency, site-specific bioconjugation, enabling the stable attachment of biomolecules under mild, aqueous conditions. It is an essential reagent for researchers and manufacturers in the biopharmaceutical and diagnostic sectors who require precise and reliable crosslinking strategies for developing antibody-drug conjugates (ADCs), protein-polymer hybrids, and advanced sensor platforms.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via the maleimide-thiol chemistry.
• PEGylation Reagent: Modification of peptides, proteins, and enzymes to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Conjugation: Labeling of antibodies, proteins, or oligonucleotides with fluorophores, enzymes, or other reporter molecules for assay development.
• Surface Functionalization: Immobilization of biomolecules onto solid supports (e.g., sensor chips, nanoparticles, microarrays) for biosensing and diagnostic applications.
• Polymer-Protein Hybrid Synthesis: Creation of advanced biomaterials and drug delivery systems by coupling functional polymers to therapeutic proteins.
• Crosslinking Agent: For the formation of stable covalent bonds between molecules containing amine and thiol functional groups.

Basic Information

Product Name	Mal-Amido-Peg24-Tfp Ester
CAS No.	2384191-62-0
Molecular Formula	Contact for details
Molecular Weight	~1500-1600 g/mol (Contact for details)
Synonyms	Maleimide-PEG24-TFP Ester; mPEG24-Mal-TFP; MAL-PEG24-TFP; Tetrafluorophenyl Ester-PEG24-Maleimide; α-Maleimide-ω-tetrafluorophenyl ester PEG; 4-Maleimidobutyric acid TFP ester-PEG; Heterobifunctional PEG Maleimide TFP Ester; TFP-PEG24-MAL
EINECS	Contact for details

Quality Control

Our Mal-Amido-Peg24-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group assay, NMR for structural confirmation, and MS for molecular weight verification, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Assay (Maleimide)	≥ 90%
Functional Group Assay (TFP Ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.