Description

Fmoc-n-Amido-Peg15-Acid CAS NO 2378590-46-4 is a specialized polyethylene glycol (PEG)-based linker molecule featuring a cleavable Fmoc-protected amine group and a terminal carboxylic acid. This bifunctional structure is critical for constructing complex, water-soluble conjugates in bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of peptide synthesis, antibody-drug conjugate (ADC) development, and prodrug design, where precise spacer length and solubility are paramount.

Application

• Bioconjugation Linker: Serves as a hydrophilic, flexible spacer for attaching payloads (e.g., drugs, toxins, dyes) to targeting molecules like antibodies, peptides, or proteins.
• ADC (Antibody-Drug Conjugate) Development: Used to create stable, cleavable linkages between cytotoxic agents and monoclonal antibodies, improving therapeutic index and solubility.
• Solid-Phase Peptide Synthesis (SPPS): Functions as a building block for introducing PEG chains into peptide sequences to enhance solubility, stability, and pharmacokinetic properties.
• Prodrug Synthesis: Enables the design of water-soluble prodrugs with controlled release mechanisms via enzymatic or chemical cleavage of the Fmoc-amido bond.
• Polymer Chemistry: Acts as a functional initiator or monomer for synthesizing tailored, biocompatible PEG-based polymers and hydrogels.
• Diagnostic Reagent Preparation: Utilized to conjugate imaging agents (e.g., fluorescent dyes, MRI contrast agents) to biomolecules for diagnostic assays.

Basic Information

Product Name	Fmoc-n-Amido-Peg15-Acid
CAS No.	2378590-46-4
Molecular Formula	C84H145NO49
Molecular Weight	~1889.06 g/mol
Synonyms	Fmoc-NH-PEG15-COOH; Fmoc-Amino-PEG15-Acid; 22,23,24,25,26,27,28,29,30,31,32,33,34,35,36-Pentadecaoxa-17-azanonatriacontanedioic acid, 17-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-15-amino-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-pentadecaoxaoctatetracontanoic acid; N-α-Fmoc-15-amino-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-pentadecaoxaoctatetracontanoic acid; Fmoc-PEG15-acid, amine-protected; Fmoc-N-amido-PEG(15)-acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-Amido-Peg15-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.