Description

Mal-Amido-Peg12-Acid CAS NO 2378428-27-2 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group for thiol conjugation and a terminal carboxylic acid for further amide coupling. This compound is engineered to provide a versatile, hydrophilic spacer arm for the site-specific crosslinking and modification of biomolecules, peptides, and surfaces. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the creation of stable, functionalized constructs for therapeutics, diagnostics, and sensors.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Linker: Site-specific coupling of cytotoxic drugs, fluorophores, or proteins to antibodies, peptides, or other targeting molecules via thiol-maleimide chemistry.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic proteins and peptides.
• Surface Functionalization: Modification of nanoparticles, quantum dots, biosensor chips, and other material surfaces to create bio-compatible, reactive interfaces for assay development.
• Crosslinking Agent: Creation of hydrogels, polymer networks, or protein-protein conjugates by reacting with thiol and amine-containing compounds.
• Diagnostic Probe Synthesis: Construction of imaging agents and diagnostic probes by linking targeting ligands to reporter molecules (e.g., dyes, chelators).
• Drug Delivery System Fabrication: Development of targeted drug delivery vehicles, such as polymer-drug conjugates and liposomal formulations.

Basic Information

Product Name	Mal-Amido-Peg12-Acid
CAS No.	2378428-27-2
Molecular Formula	C58H108N2O28 (Tentative)
Molecular Weight	~1281.5 g/mol (Tentative)
Synonyms	Maleimide-PEG12-acid; Maleimido-PEG12-COOH; MAL-PEG12-Acid; 3-Maleimidopropionic acid-PEG12-acid; α-Maleimido-ω-carboxy PEG12; PEG12 Maleimide Acid; N-(3-Maleimidopropionyl)-PEG12-acetic acid; Heterobifunctional PEG 12-arm Maleimide Acid
EINECS	Contact for details

Quality Control

Our Mal-Amido-Peg12-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent performance, and batch-to-batch reproducibility. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and functional group integrity via techniques such as HPLC, NMR, and MS. Our production adheres to cGMP principles where applicable, supporting its use in research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Maleimide Functional Group Assay	≥ 90% of theoretical
Acid Value (Titration)	Conforms to theoretical range

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.