Description

K-Ras Ligand-Linker Conjugate 3 is a high-purity synthetic intermediate designed for advanced pharmaceutical research and development. This compound is critical for the targeted development of covalent inhibitors against the challenging K-Ras G12C oncoprotein, a key driver in various cancers. It is an essential building block for medicinal chemists and research organizations engaged in the discovery of next-generation oncology therapeutics. The product, identified by CAS number 2378261-87-9, meets the stringent requirements for precision and reliability in drug discovery pipelines.

Application

This specialized conjugate serves as a pivotal component in several high-value research and development areas:

• Prototype Drug Synthesis: A key precursor for synthesizing covalent inhibitor candidates targeting the K-Ras G12C mutation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Oncology Drug Discovery: Integral to R&D programs focused on non-small cell lung cancer (NSCLC), pancreatic cancer, and colorectal cancer.
• Bioconjugation & Probe Development: Enables the creation of chemical probes for studying K-Ras biology and signaling pathways.
• Preclinical Development: Supports the synthesis of compounds for in vitro and in vivo efficacy and pharmacokinetic studies.

Basic Information

Product Name	K-Ras Ligand-Linker Conjugate 3
CAS No.	2378261-87-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KRAS G12C Ligand-Linker Conjugate 3; K-Ras Inhibitor Conjugate 3; Covalent KRAS Inhibitor Intermediate; (S)-1-((2S,4R)-4-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)ethoxy)acetamido)-2-methyl-5-oxopyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl 2-((6S,9S,12S,15S)-6,9-bis(2-((tert-butoxycarbonyl)amino)ethyl)-12-(3-((tert-butoxycarbonyl)amino)propyl)-15-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-5,8,11,14,17-pentaazaoctadecan-18-yl)acetate; ARS-1620 Analog Conjugate; PROTAC Linker Conjugate for KRAS
EINECS	Contact for details

Quality Control

Our K-Ras Ligand-Linker Conjugate 3 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated at the recommended temperature.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.