Description

Fmoc-Nh-Peg10-Ch2Cooh is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and linker chemistry. This compound is critical for creating stable, hydrophilic spacers in the development of peptide-based therapeutics, antibody-drug conjugates (ADCs), and diagnostic probes. It is primarily utilized by research scientists and process development teams in the pharmaceutical, biotechnology, and life science sectors for precise molecular engineering.

Application

• As a versatile linker in the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics.
• For constructing hydrophilic spacers in antibody-drug conjugates (ADCs) to improve solubility and pharmacokinetic profiles.
• In the site-specific modification of proteins and antibodies for diagnostic and therapeutic applications.
• As a key building block for functionalizing surfaces and nanoparticles to enhance biocompatibility.
• For the synthesis of PEGylated drug candidates to reduce immunogenicity and increase circulation time.
• In proteomics research for labeling and cross-linking experiments.

Basic Information

Product Name	Fmoc-Nh-Peg10-Ch2Cooh
CAS No.	2375105-88-5
Molecular Formula	C58H95N3O26
Molecular Weight	1234.4 g/mol (Contact for exact value)
Synonyms	Fmoc-NH-PEG10-CH2COOH; Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9H-fluoren-9-ylmethoxy)carbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Fmoc-PEG10-acid; Fmoc-Amino-PEG10-Acid; Fmoc-N-amido-PEG10-acid; N-α-Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Nh-Peg10-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your GMP-compliant research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.