Description

-Peg4-Amine CAS NO 2357105-92-9 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a primary amine group, making it a versatile linker for bioconjugation and chemical synthesis. This compound is critical for creating stable, water-soluble conjugates in advanced pharmaceutical and diagnostic applications. It is primarily needed by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and advanced material science for developing targeted drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation Linker: For coupling peptides, proteins, antibodies, or oligonucleotides to other molecules, surfaces, or nanoparticles.
• PEGylation Reagent: Used to modify therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Crosslinking Agent: In the synthesis of hydrogels, polymer networks, and biomaterials requiring amine-reactive chemistry.
• Diagnostic Probe Synthesis: Building block for fluorescent dyes, MRI contrast agents, and other imaging probes.
• Surface Functionalization: Amination of materials like glass, gold, or polymers for subsequent immobilization of biomolecules.
• Antibody-Drug Conjugate (ADC) Development: As a component of the linker-payload system connecting cytotoxic drugs to monoclonal antibodies.
• Solid-Phase Peptide Synthesis (SPPS): As a soluble PEG-based support or as a building block to introduce PEG spacers into peptide sequences.
• Nanoparticle Modification: To impart stealth properties and provide reactive amine handles on liposomes, dendrimers, or polymeric nanoparticles.

Basic Information

Product Name	-Peg4-Amine
CAS No.	2357105-92-9
Molecular Formula	C17H35NO7
Molecular Weight	365.47 g/mol
Synonyms	15-Amino-4,7,10,13-tetraoxapentadecanoic Acid; Amino-PEG4-acid; Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic Acid (protected form); 2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]acetic Acid; H2N-PEG4-COOH; 15-Amino-PEG4-acid; 4,7,10,13-Tetraoxa-16-azaoctadecanoic Acid; Amino-PEG4-Acid
EINECS	Contact for details

Quality Control

Our -Peg4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Assay (NMR/Titration)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.