Description

Gly-Peg3-Endo-Bcn CAS NO 2354291-37-3 is a specialized bifunctional linker molecule featuring an endo-BCN (bicyclo[6.1.0]nonyne) group and a glycine-PEG3 moiety, designed for advanced bioconjugation applications. This compound is critical for enabling rapid, selective, and bioorthogonal click chemistry reactions, particularly with azide-functionalized molecules, under mild physiological conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and antibody-drug conjugate (ADC) synthesis, where precise and stable linkage is paramount.

Application

• Antibody-Drug Conjugate (ADC) Payload Linkage: Used to connect cytotoxic drugs to monoclonal antibodies via bioorthogonal click chemistry.
• Protein and Peptide Labeling: Facilitates site-specific modification of proteins for imaging, tracking, or functional studies.
• Surface Functionalization: Enables the immobilization of biomolecules onto nanoparticles, biosensors, or microarray slides.
• Polymer and Dendrimer Modification: Serves as a key building block for creating functionalized polymers with tailored biological activity.
• Chemical Biology Probes: Integral for synthesizing activity-based probes to study enzyme function and metabolic pathways.
• Diagnostic Reagent Development: Used in the creation of sensitive and specific diagnostic assays and imaging agents.

Basic Information

Product Name	Gly-Peg3-Endo-Bcn
CAS No.	2354291-37-3
Molecular Formula	C₂₀H₃₄N₂O₆
Molecular Weight	398.5 g/mol
Synonyms	Glycine-PEG3-endo-BCN; endo-BCN-PEG3-Gly-OH; (1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11-tetraoxatetradecan-14-yl)carbamate; BCN-PEG3-Glycine; endo-BCN-PEG3-Glycine; BCN-PEG3-Gly-OH; Gly-PEG3-endo-Bicyclo[6.1.0]nonyne
EINECS	Contact for details

Quality Control

Every batch of Gly-Peg3-Endo-Bcn is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure high purity and batch-to-batch consistency. Our products are suitable for research and development use under cGMP guidelines. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically >95% by HPLC), and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.