Description

Dbco-Peg9-Amine CAS NO 2353409-99-9 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a primary amine for further conjugation. This compound is essential for creating stable, bioorthogonal linkages in aqueous environments without the need for cytotoxic copper catalysts. It is primarily needed by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science for constructing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Used as a key linker for site-specific conjugation of cytotoxic drugs to monoclonal antibodies via SPAAC click chemistry.
• PEGylation Reagent: Enables the attachment of a hydrophilic PEG9 spacer to peptides, proteins, or small molecules to improve solubility, stability, and pharmacokinetics.
• Surface Functionalization: Facilitates the modification of nanoparticles, biosensors, and microarray slides with amine-reactive probes or biomolecules.
• Hydrogel and Biomaterial Synthesis: Serves as a crosslinker or functional component in the creation of smart, responsive biomaterials for drug delivery and tissue engineering.
• Diagnostic Probe Synthesis: Employed in the construction of fluorescent, radioactive, or other labeled probes for in vitro and in vivo imaging.
• Chemical Biology Tool: A critical reagent for labeling and studying biomolecules in live cells using bioorthogonal chemistry techniques.

Basic Information

Product Name	Dbco-Peg9-Amine
CAS No.	2353409-99-9
Molecular Formula	C45H73N3O11
Molecular Weight	832.1 g/mol
Synonyms	DBCO-PEG9-NH2; DBCO-PEG9-Amine; Dibenzocyclooctyne-PEG9-Amine; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl N-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-Aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)carbamate; Azadibenzocyclooctyne-PEG9-Amine; ADIBO-PEG9-NH2; DBCO-PEG9-Amine; DBCO-(PEG)9-Amine
EINECS	Contact for details

Quality Control

Our Dbco-Peg9-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency for critical research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, water, common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.