Description

Tco-Peg6-Amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a thermolabile TCO (trans-cyclooctene) group and a primary amine terminus. This compound is engineered for advanced bioconjugation, enabling rapid and selective click chemistry reactions under mild, physiological conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require efficient and stable modification of biomolecules.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Facilitates the site-specific attachment of cytotoxic payloads, fluorophores, or other functional molecules to antibodies, proteins, or peptides via the amine-reactive end.
• Bioorthogonal Labeling and Imaging: Utilizes the TCO group for rapid, tetrazine-mediated inverse electron demand Diels-Alder (IEDDA) click chemistry in live-cell imaging and in vivo diagnostics.
• PEGylation and Linker Chemistry: Serves as a hydrophilic spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic biomolecules and nanoparticles.
• Surface Functionalization: Used to modify solid supports, biosensors, and microarray surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Prodrug Synthesis: Enables the creation of cleavable prodrug linkers where the TCO group can be triggered for controlled drug release.
• Materials Science: Incorporation into hydrogels and polymeric materials to introduce bio-reactive handles for tissue engineering and drug delivery systems.

Basic Information

Product Name	Tco-Peg6-Amine
CAS No.	2353409-94-4
Molecular Formula	C31H58N2O8
Molecular Weight	586.8 g/mol
Synonyms	trans-Cyclooctene-PEG6-amine; TCO-PEG6-NH2; (E)-Cyclooct-4-enyl 2,5,8,11,14,17-hexaoxanonadecan-19-oate; TCO-PEG6-Amine; Amine-PEG6-TCO; 19-Amino-4,7,10,13,16,19-hexaoxa-2-azanonadecan-1-yl (E)-cyclooct-4-ene-1-carboxylate; TCO-PEG(6)-NH2; TCO-(PEG)6-amine
EINECS	Contact for details

Quality Control

Our Tco-Peg6-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and moisture content are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, methanol, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.