Description

Diketone-Peg4-Pfp Ester CAS NO 2353409-84-2 is a specialized bifunctional linker molecule featuring a diketone group and a pentafluorophenyl (PFP) ester, connected by a tetraethylene glycol (PEG4) spacer. This compound is engineered for high-efficiency conjugation chemistry, enabling the stable attachment of molecules containing amine or hydrazine groups to various substrates under mild conditions. It is an essential intermediate for researchers and manufacturers in bioconjugation, proteomics, and advanced materials science, particularly for creating targeted drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation Reagent: For site-specific labeling of antibodies, proteins, peptides, and oligonucleotides with fluorescent dyes, drugs, or other functional moieties.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and chemoproteomics to tag and identify enzyme active sites.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker-payload component for constructing stable, homogeneous ADCs with controlled drug-to-antibody ratios (DAR).
• Surface Functionalization: Enables the covalent immobilization of biomolecules onto nanoparticles, biosensors, microarrays, and other solid supports.
• Polymer and Materials Chemistry: Acts as a crosslinking agent or functional monomer for synthesizing smart polymers and hydrogels with responsive properties.
• Diagnostic Kit Manufacturing: Utilized in the production of enzyme-linked immunosorbent assay (ELISA) kits and other in-vitro diagnostic (IVD) reagents.

Basic Information

Product Name	Diketone-Peg4-Pfp Ester
CAS No.	2353409-84-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PFP-PEG4-Diketone; Pentafluorophenyl-PEG4-Diketone Ester; Diketone-PEG4-PFP; Tetraethylene glycol diketone PFP ester; 2,5-Dioxohexanoic acid-PEG4-PFP ester; PFP ester of Diketone-PEG4-acid; Bioconjugation linker 2353409-84-2; Amine-reactive PEG linker with diketone and PFP ester
EINECS	Contact for details

Quality Control

Our Diketone-Peg4-Pfp Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.