Description

Biotin-Peg7-Thiourea is a high-purity, heterobifunctional crosslinking reagent designed for advanced bioconjugation. This compound is critical for researchers and manufacturers requiring precise, stable linkages between biotinylated molecules and other functional groups, such as thiols or amines, via its reactive thiourea moiety and extended polyethylene glycol (PEG) spacer. It is primarily utilized in the development of diagnostic assays, targeted drug delivery systems, and advanced materials within the pharmaceutical, biotechnology, and life science research sectors.

Application

• Bioconjugation and Crosslinking: For creating stable covalent bonds between biotinylated probes (e.g., antibodies, peptides) and nanoparticles, surfaces, or other biomolecules.
• Diagnostic Kit Development: As a key reagent in the synthesis of components for ELISA, lateral flow assays, and other biosensors requiring high-affinity streptavidin-biotin interactions.
• ADC (Antibody-Drug Conjugate) Research: Enables the site-specific attachment of cytotoxic payloads or imaging agents to targeting antibodies via the PEGylated linker.
• Surface Functionalization: Used to modify gold nanoparticles, quantum dots, or microarray slides with biotin for capture and detection applications.
• Affinity Chromatography: Synthesis of ligands for immobilizing streptavidin/avidin on solid supports to purify or capture target molecules.
• Polymer and Biomaterial Science: Incorporation into hydrogels or polymeric scaffolds to introduce biotin handles for subsequent functionalization.

Basic Information

Product Name	Biotin-Peg7-Thiourea
CAS No.	2353409-59-1
Molecular Formula	C33H61N5O10S2
Molecular Weight	751.99 g/mol
Synonyms	Biotin-PEG7-isothiocyanate; Biotin-PEG7-NCS; Biotin-PEG7-Thiourea; 5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[2-[2-[2-(isothiocyanatoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]pentanamide; Biotin-PEG7-ITC; PEG7-Biotin-NCS; Biotinylated PEG7 Isothiocyanate
EINECS	Contact for details

Quality Control

Our Biotin-Peg7-Thiourea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.