Description

Biotin-Peg4-Dde-Tamra-Peg3-Azide is a multifunctional, high-purity chemical reagent designed for advanced bioconjugation and bioorthogonal labeling applications. This compound integrates biotin for streptavidin capture, a cleavable Dde protecting group, a TAMRA fluorophore for visualization, and a terminal azide for copper-free click chemistry. It is essential for researchers and developers in the life sciences sector who require precise, multi-step labeling strategies for proteins, antibodies, and other biomolecules. The product is supplied under stringent quality control to ensure batch-to-batch consistency and optimal performance in sensitive assays.

Application

• Proteomics Research: Site-specific labeling and purification of proteins using the biotin-streptavidin interaction combined with fluorescent detection.
• Antibody-Drug Conjugate (ADC) Development: Facilitating the construction and analysis of ADC linker-payload systems via bioorthogonal chemistry.
• Live-Cell Imaging: Labeling of cell surface proteins or intracellular targets with the TAMRA fluorophore for real-time tracking.
• Diagnostic Assay Development: Creating sensitive detection platforms (e.g., ELISA, flow cytometry) with built-in purification and signal amplification steps.
• Chemical Biology Probes: Synthesis of activity-based probes for enzyme profiling or target identification studies.
• Materials Science: Functionalization of nanoparticles or surfaces with biologically active ligands for biosensor applications.

Basic Information

Product Name	Biotin-Peg4-Dde-Tamra-Peg3-Azide
CAS No.	2353409-56-8
Molecular Formula	C84H119N15O24S
Molecular Weight	1690.0 g/mol (Contact for exact value)
Synonyms	Biotin-PEG4-Dde-TAMRA-PEG3-azide; TAMRA-PEG3-Azide-Biotin-PEG4-Dde; 5(6)-TAMRA-PEG3-azide-PEG4-Biotin-Dde; Dde-Biotin-PEG4-TAMRA-PEG3-N3; Biotinylated TAMRA Azide Probe; Biotin-PEG4-(Dde)-TAMRA-PEG3-N3; N-(Biotin-PEG4)-N'-(TAMRA-PEG3-azide)-Dde; Bioorthogonal Labeling Reagent with Biotin, Dde, and TAMRA
EINECS	Contact for details

Quality Control

Every batch of Biotin-Peg4-Dde-Tamra-Peg3-Azide undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and development. Our quality assurance protocol includes HPLC for purity confirmation, mass spectrometry (MS) for identity verification, and NMR for structural validation. Certificates of Analysis (COA) detailing all test results are available upon request. We adhere to a quality management system to guarantee supply reliability and product consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store under an argon or nitrogen atmosphere.

Specification

Item	Specification
Appearance	Red to purple solid or film
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.