Description

N2-Isobutyryl-O6-Cyanoethyl-7'-Oh-n-Trityl-Morpholino Guanine is a sophisticated, multi-protected nucleoside phosphoramidite derivative, a critical building block in the automated synthesis of oligonucleotides. This compound is engineered to provide exceptional coupling efficiency and stability during solid-phase synthesis, ensuring high yields and purity of the final oligonucleotide product. It is an essential raw material for research and development in molecular biology, diagnostics, and therapeutic applications, particularly for antisense oligonucleotides, siRNAs, and aptamers.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the automated solid-phase synthesis of DNA and RNA strands.
• Therapeutic Oligonucleotide R&D: Used in the development of antisense drugs, siRNA therapeutics, and aptamers for targeted gene silencing and regulation.
• Diagnostic Probe Manufacture: Essential for producing high-purity labeled probes for PCR, FISH, and microarray technologies.
• Synthetic Biology: A building block for constructing novel genetic circuits, modified genes, and non-natural nucleic acid analogs.
• Academic & Industrial Research: Supports fundamental research in genomics, virology, and molecular pharmacology requiring custom oligonucleotides.
• CRISPR/Cas9 Guide RNA Synthesis: Used in the production of synthetic guide RNAs (sgRNAs) for genome editing applications.

Basic Information

Product Name	N2-Isobutyryl-O6-Cyanoethyl-7'-Oh-n-Trityl-Morpholino Guanine
CAS No.	2305415-83-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7'-OH-DMT-G(Ibu) Morpholino-CE Phosphoramidite; N2-Ibu-7'-OH-DMT-G Morpholino-CE Phosphoramidite; Guanosine, N2-(2-methyl-1-oxopropoxy)-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(4-morpholinyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; DMT-G(Ibu) Morpholino-CE Phosphoramidite; 2'-O-Morpholino Modified Guanine Phosphoramidite; 7'-O-DMT-2'-O-Morpholino-N2-Ibu-G-CE Phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of N2-Isobutyryl-O6-Cyanoethyl-7'-Oh-n-Trityl-Morpholino Guanine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive oligonucleotide synthesis. Our quality assurance protocol includes comprehensive characterization by HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and performance-critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under anhydrous conditions. The product is hygroscopic (moisture-sensitive) and should be handled in a dry, inert atmosphere or with appropriate desiccant to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.