Description

Azido-Peg35 Amine is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a primary amine terminus. This bifunctionality is critical for creating stable, biocompatible conjugates and cross-linked materials via click chemistry and amine coupling reactions. It is an essential building block for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the precise modification of biomolecules, surfaces, and nanoparticles.

Application

• Bioconjugation and Linker Chemistry: Used as a heterobifunctional cross-linker to attach drugs, dyes, or targeting ligands to antibodies, proteins, and peptides via sequential click chemistry (azide-alkyne cycloaddition) and amine-reactive coupling.
• PEGylation Reagent: Serves as a functionalized PEG spacer to introduce amine handles onto azide-functionalized molecules, improving solubility, stability, and pharmacokinetics of therapeutic agents.
• Surface Functionalization: Employed to modify material surfaces (e.g., gold nanoparticles, quantum dots, polymers) with amine groups for subsequent immobilization of biomolecules or further chemical modification.
• Hydrogel and Polymer Synthesis: Acts as a key monomer or cross-linking agent in the synthesis of PEG-based hydrogels and smart polymers for drug delivery and tissue engineering applications.
• Diagnostic Probe Development: Facilitates the construction of advanced diagnostic probes and imaging agents by linking reporting moieties to targeting molecules.
• Click Chemistry Scaffold: Provides a versatile platform for modular synthesis in combinatorial chemistry and library generation for drug discovery.

Basic Information

Product Name	Azido-Peg35 Amine
CAS No.	2301851-71-6
Molecular Formula	C71H143N5O36 (Typical for PEG35 chain)
Molecular Weight	~1686.9 g/mol (Theoretical average)
Synonyms	Azido-PEG35-amine; α-Azido-ω-amino-pentaethylene glycol; N3-PEG35-NH2; 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86,89,92,95,98,101,104-Heptatriacontaoxa-2,104-diazapentane-1,105-diyldiazide; Amine-PEG35-Azide; Heterobifunctional PEG Azide Amine; Azido-Polyethylene Glycol-Amine
EINECS	Contact for details

Quality Control

Our Azido-Peg35 Amine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, functional group integrity, and absence of critical impurities. We adhere to cGMP principles where applicable to support our clients in pharmaceutical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95%
Amine Value (Titration)	Contact for details
Azide Content	Contact for details
Average Molecular Weight (GPC)	~1600 - 1750 Da
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO, DMF, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.