Description

Oleic-Dbco CAS NO 2279951-78-7 is a high-purity, bifunctional chemical reagent that combines the bioorthogonal reactivity of a dibenzocyclooctyne (DBCO) group with the lipophilic properties of an oleic acid chain. This unique structure makes it an essential tool for advanced bioconjugation and labeling strategies, particularly in lipid and membrane research. It is primarily utilized by researchers and product developers in the pharmaceutical, biotechnology, and diagnostic sectors who require efficient, copper-free click chemistry for modifying biomolecules, nanoparticles, and surfaces.

Application

• Lipid and Lipoprotein Labeling: Conjugation of DBCO-tagged probes (e.g., fluorophores, biotin) to oleic acid-containing lipids for cellular imaging and tracking studies.
• Nanoparticle Functionalization: Surface modification of lipid-based nanoparticles (LNPs, liposomes) to introduce azide-reactive sites for targeted drug delivery systems.
• Bioconjugation Linker: Serves as a hydrophobic spacer or linker to attach azide-modified peptides, antibodies, or oligonucleotides to lipid membranes or hydrophobic interfaces.
• Chemical Biology Probes: Synthesis of activity-based probes for studying lipid-metabolizing enzymes or membrane-associated proteins via bioorthogonal chemistry.
• Materials Science: Incorporation into polymers or coatings to create azide-reactive surfaces for biosensor development or biomaterial engineering.
• Diagnostic Assay Development: Preparation of capture reagents for immunoassays or lateral flow tests that require stable, covalent attachment to lipid carriers.

Basic Information

Product Name	Oleic-Dbco
CAS No.	2279951-78-7
Molecular Formula	C35H53NO3
Molecular Weight	535.80 g/mol
Synonyms	(Z)-Octadec-9-enoic acid DBCO conjugate; DBCO-Oleic Acid; N-(3-(Dibenzocyclooctyn-10-yl)propyl)-9Z-octadecenamide; Oleic Acid-DBCO; DBCO-C18:1; 10-(3-((Z)-Octadec-9-enamido)propyl)dibenzocyclooctyn-10-ol; DBCO-PEG0-Oleic Acid; Azadibenzocyclooctyne-Oleic Acid conjugate
EINECS	Contact for details

Quality Control

Our Oleic-Dbco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, THF, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.